30
Apr
2019
Abstract
The influence of polyphenolic extracts from Annurca apple peel and flesh on lipid metabolism in human hepatocellular liver carcinoma (HepG2) cell lines was evaluated, and compared with those of other conventional cultivars, such as Red Delicious (RD), Pink Lady (PL), Fuji (F) and Golden Delicious (GD). Annurca flesh revealed the best inhibition capacity against lipase activity, and triglyceride levels in the cell medium increased by almost 20 times above control levels. Incubation with Annurca flesh polyphenols enhanced low-density lipoproteins (LDL) receptor binding activity by 40% and led to an increase in Apolipoprotein A1 (ApoA1) cell expression of 33.3% above control levels.